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Carboxin can induce cardiotoxicity in zebrafish embryos
Yong Huang1, Ziqin Wang2, Yuyang Peng2
1Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000, Jiangxi, China; College of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou 341000, Jiangxi, China.
Ecotoxicology and Environmental Safety
|February 19, 2022
Summary
Carboxin fungicide causes developmental and heart toxicity in zebrafish embryos, leading to heart failure and death. This study reveals its adverse effects on aquatic organisms, highlighting potential environmental risks.
Area of Science:
- Environmental Toxicology
- Aquatic Toxicology
- Fungicide Toxicity
Background:
- Carboxin is a systemic fungicide used in agriculture.
- Mammalian toxicity of Carboxin is known, but aquatic toxicity is not.
- Zebrafish are a model organism for studying aquatic toxicity.
Purpose of the Study:
- To investigate the toxicity of Carboxin in zebrafish embryos.
- To assess the impact of Carboxin on cardiac development and function.
- To explore the mechanisms underlying Carboxin-induced toxicity.
Main Methods:
- Zebrafish embryos were exposed to Carboxin.
- Histopathological staining and fluorescence quantitative PCR were used to analyze cardiac structure and gene expression.
- Oxidative stress markers, mitochondrial function, and cell proliferation were assessed.
Main Results:
- Carboxin exposure resulted in developmental toxicity and cardiotoxicity in zebrafish embryos.
- Structural heart changes, disrupted gene expression, and increased reactive oxygen species (ROS) were observed.
- Mitochondrial damage, decreased ATPase activity, reduced blood cell counts, and inhibited myocardial cell proliferation were evident.
Conclusions:
- Carboxin induces significant cardiotoxicity and developmental toxicity in zebrafish.
- Oxidative stress and mitochondrial dysfunction are key mechanisms of Carboxin toxicity.
- Carboxin poses a risk to aquatic organisms, necessitating further environmental risk assessment.
