Bioactive terpenoids derived from plant endophytic fungi: An updated review (2011-2020)

Plant endophytes have been considered as novel sources of naturally occurring compounds with various biological activities, including cytotoxic, antimicrobial, anti-inflammatory, anticancer, herbicides, antileishmanial and antioxidant. A variety of specialised products, comprising terpenoids, alkaloids, polyketides, phenolic compounds, coumarins, and quinone derivatives have been reported from various strains. An increasing number of products, especially terpenoids, are being isolated from endophytes. Herein, the isolated new terpenoids from plant endophytic fungi, their hosts, as well as biological activities, from January 2011 until the end of 2020 are reviewed. In this period, 516 terpenoids are classified into monoterpenes (5), sesquiterpenes (299), diterpenes (76), sesterterpens (22), meroterpenes (83), triterpenes (29), and other terpenoids (2), were isolated from different plant endophytic fungi species.