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Histone deacetylase inhibitor-based oncolytic virotherapy: A promising strategy for cancer treatment

Ekta Shirbhate1, Ravichandran Veerasamy2, Sai H S Boddu3

  • 1Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur 495 009, CG, India.

Drug Discovery Today
|February 20, 2022
PubMed

Insights

Oncolytic viruses (OVs) show promise for cancer treatment due to their tumor specificity and safety. Combining OVs with other therapies may enhance efficacy and reduce side effects for improved cancer care.

Area of Science:

  • Oncology
  • Virology
  • Cancer Therapeutics

Background:

  • Cancer treatment faces challenges with declining drug efficacy and adverse effects.
  • Oncolytic viruses (OVs) are emerging as a promising cancer therapy due to their cancer-specific targeting and reduced side effects.
  • Clinical trials indicate OVs possess an acceptable safety profile and efficacy in specific cancers.

Purpose of the Study:

  • To explore the potential of oncolytic viruses (OVs) in cancer treatment.
  • To identify strategies for enhancing the effectiveness of oncolytic virotherapy.
  • To investigate the combination of OVs with conventional cancer treatments.

Main Methods:

  • Review of current clinical trial data on oncolytic viruses.
  • Analysis of factors limiting OV efficacy, including tumor permeation and delivery.
  • Exploration of combination therapies involving OVs and targeted drugs.

Main Results:

  • Oncolytic viruses demonstrate specificity for cancerous tissues and a favorable safety profile.
  • Current OV applications are limited by challenges in tumor penetration and delivery.
  • Combining OVs with targeted inhibitors, like histone deacetylase inhibitors, is a potential strategy for improvement.

Conclusions:

  • Oncolytic virotherapy offers a targeted approach to cancer treatment with reduced adverse effects.
  • Further research is needed to optimize OV delivery and tumor permeation for broader application.
  • Combination strategies hold promise for developing safer, more effective, and reliable cancer therapeutics.
Keywords:
CancerCombination therapyHistone deacetylaseHistone deacetylase inhibitorsOncolytic virusVirotherapy

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