Related Experiment Video
Updated: Oct 3, 2025

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
Promoting enteral tube feeding safety and performance in preterm infants: A systematic review
Tian Lin1, Jiale Hu2, Lifeng Zhang3
1School of Nursing, Guangdong Pharmaceutical University, 183 Jianghai Avenue, Guangzhou, China; School of Humanities and Social Sciences, Macao Polytechnic Institute, Macao, China.
Insights
Nurses use various practices to enhance enteral tube feeding safety and performance in preterm infants. Oro-motor stimulation and non-nutritive sucking show effectiveness in promoting feeding performance.
Area of Science:
- Neonatal care
- Pediatric nursing
- Clinical nutrition
Background:
- Enteral tube feeding is vital for preterm infant nutrition.
- Nurses are key to ensuring feeding safety and performance.
- This review focuses on nursing interventions for enteral tube feeding in preterm infants.
Purpose of the Study:
- To identify nursing practices for feeding safety and performance in preterm infants receiving enteral tube feeding.
- To summarize the evidence on the effectiveness of these nursing practices.
Main Methods:
- A systematic review of 61 studies (47 RCTs, 14 quasi-experimental) was conducted.
- Searches included six major databases.
- Risk of bias was assessed using established tools (RoB 2, ROBINS-I).
- Narrative synthesis was used for data analysis.
Main Results:
- Seven categories of nursing practices were identified.
- Practices include feeding intervals, position, gastric residual management, temperature, stimulation, and transition methods.
- Oro-motor stimulation and non-nutritive sucking demonstrated effectiveness in promoting feeding performance.
- Other practices require further investigation due to limited evidence.
Conclusions:
- Seven categories of nursing practices for enteral tube feeding in preterm infants were identified.
- Oro-motor stimulation and non-nutritive sucking are recommended for clinical use.
- Further research is needed to support other practices, which are currently based on local preference and cost.
Background:
Enteral tube feeding is commonly used in preterm infants to provide enteral nutrition. Nurses play a crucial role in promoting feeding safety and performance.
Objectives:
The aims of this systematic review were to identify nursing practices regarding feeding safety and performance promotion in preterm infants with enteral tube feeding and summarize evidence on the effectiveness of these practices.
Methods:
A comprehensive search was performed in six databases (MEDLINE, EMBASE, CINAHL, Web of Science, Cochrane Library, and Scopus). Studies on nursing practices aimed at promoting feeding safety and performance in preterm infants with enteral tube feeding were included. Risk of bias was assessed using the revised Cochrane risk-of-bias tool for randomized trials (RoB 2) for randomized controlled studies and the tool of risk-of-bias in non-randomized studies of interventions (ROBINS-I) for non-randomized studies of interventions. A narrative synthesis strategy was employed to gather evidence and analyze data.
Results:
61 studies (47 randomized controlled studies and 14 quasi-experimental studies) covering seven categories of practices were included. The identified nursing practices included controlling feeding interval, selecting feeding position, monitoring gastric residual, disposing of gastric residual, managing feeding temperature, feeding promotion stimulation, and supplementary methods during the transition from tube to oral feeding. Evidence supported the effectiveness of oro-motor stimulation and non-nutritive sucking as feeding performance promotion strategies in preterm infants. Other practices were suggested to be used cautiously or recommended to be further studied due to limited evidence.
Conclusions:
The review identified seven categories of nursing practices in promoting feeding safety and performance in preterm infants receiving enteral tube feeding. Oro-motor stimulation and non-nutritive sucking can be used in clinical settings to promote feeding performance in preterm infants with enteral tube feeding. Other practices will continue to be dictated by local preferences and cost factors until more robust evidence becomes available.
Registration:
PROSPERO database (CRD42020196256).
Related Concept Videos
Enteral Nutrition I: Orogastric and Nasogastric Feeding
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
Endotracheal Intubation I: Procedure
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...
Endotracheal Tube Extubation
Procedure
Extubation removes the endotracheal tube (ETT) from the patient on mechanical ventilation. It requires a well-coordinated, multidisciplinary approach involving physicians, nurses, respiratory therapists, and other healthcare professionals....
Endotracheal Intubation II: Nursing Management
1. Nursing Care of Patients Before Intubation
Before the endotracheal intubation procedure, nurses play an essential role in ensuring the process goes smoothly. The nurses must be familiar with intubation...
Drug Delivery: Enteral Route

