PVP-coated silver nanocubes as RRS probe for sensitive determination of Haloperidol in real samples

Polyol synthesis of silver nanocubes (Ag NCs) under dark conditions yielded nanoparticles with high uniformity and purity, as well as edge lengths of 42 nm with good stability and scattering cross-section. These nanoparticles were characterized by SEM, TEM, and Uv-vis spectroscopy. The presence of polyvinylpyrrolidone (PVP) as a capping agent on the surface of Ag NCs, as well as its satisfactory interaction level with Haloperidol (Hp) as an antipsychotic drug, has led to the use of these nanoparticles as Resonance RayleighScattering (RRS) probe to measure Hp. Indeed, Hp resulted in reducing the RRS signal of Ag NCs, and this change in RRS intensity was linear in the range of 10.0 to 800.0 µg L^-1 of Hp. The limits of detection (LOD) and quantification (LOQ) were found to be 1.5 and 5.0 µg L^-1, respectively. The influence of interfering species was studied, and it was found that the suggested method has good selectivity and can be used to monitor Hp in actual samples. As a result, this RRS probe operated well in determining Hp in pharmaceutical and human plasma samples with satisfactory recovery.