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Coupling of brain activity and structural network in multiple sclerosis: A graph frequency analysis study.

Chenfei Ye1, Jing Huang2,3, Li Liang4

  • 1Peng Cheng Laboratory, Shenzhen, China.

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|February 20, 2022
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Summary

Multiple sclerosis (MS) disrupts brain wiring and function. This study reveals altered structural-functional coupling in MS, impacting networks and cognitive function, offering a unique signature of brain reorganization.

Keywords:
brain structural networkclinically isolated syndromegraph frequency analysismultiple sclerosisresting-state fMRI

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Systems Biology

Background:

  • Multiple sclerosis (MS) affects brain structure and function.
  • The relationship between structural and functional brain changes in MS is not fully understood.

Purpose of the Study:

  • To investigate the complex coupling between structural and functional brain properties in MS.
  • To quantify high-order structural-functional interactions using graph frequency analysis.

Main Methods:

  • Utilized diffusion MRI and functional MRI data.
  • Applied graph frequency analysis to assess structural-functional decoupling.
  • Proposed a structural-functional decoupling index to measure organization of functional activity atop the structural wiring diagram.

Main Results:

  • Identified disrupted structural-functional coupling in the somatomotor network (β = 0.05, p = 0.03).
  • Observed decreased decoupling in subcortical, visual, and dorsal attention networks (p < 0.05).
  • Found association between somatomotor network coupling and cognitive decline in MS patients (β = -24.31, p = 0.006).

Conclusions:

  • Unveiled a unique signature of brain structural-functional reorganization in MS.
  • Demonstrated specific network disruptions and their link to cognitive impairment.