Related Experiment Video

Updated: Oct 3, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.7K

Poor pulmonary function is associated with mild cognitive impairment, its progression to dementia, and brain

Jiao Wang1,2,3, Abigail Dove4, Ruixue Song1,5

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|February 20, 2022
PubMed
Abstract

Insights

Poor pulmonary function (PF) is linked to increased risk of mild cognitive impairment (MCI) and dementia. Low PF may also accelerate MCI progression to dementia through brain pathologies.

Area of Science:

  • Neurology
  • Pulmonology
  • Gerontology

Background:

  • The connection between pulmonary function (PF) and cognitive decline, including mild cognitive impairment (MCI) and dementia, is not fully understood.
  • Brain pathologies underlying cognitive impairment require further investigation in relation to respiratory health.

Purpose of the Study:

  • To investigate the association between baseline pulmonary function and the incidence and progression of mild cognitive impairment (MCI) and dementia.
  • To explore the relationship between pulmonary function and neuropathological findings, including Alzheimer's disease and vascular pathology.

Main Methods:

  • A longitudinal study followed 1312 dementia-free participants (cognitively intact and MCI groups) for up to 21 years.
  • Pulmonary function was assessed at baseline using a composite score.
  • Neuropathological assessment through autopsy was performed on 540 participants.

Main Results:

  • Lowest PF was associated with a 1.95-fold increased hazard for MCI in cognitively intact individuals.
  • Lowest PF was associated with a 1.55-fold increased hazard for dementia in the MCI group.
  • Low PF correlated with both Alzheimer's disease (OR 1.32) and vascular pathology (OR 3.05).

Conclusions:

  • Reduced pulmonary function is a significant risk factor for developing MCI and progressing to dementia.
  • Both neurodegenerative and vascular mechanisms may mediate the link between poor pulmonary function and dementia.
  • Pulmonary health may play a crucial role in maintaining cognitive function and preventing dementia.
Keywords:
brain pathologycohort studydementiamild cognitive impairmentpulmonary function

More Related Videos

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

32.8K
Using Retinal Imaging to Study Dementia09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.8K

Related Concept Videos

Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
204
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
713
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
662
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
355
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.6K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.2K