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Updated: Oct 3, 2025

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
Published on: June 16, 2011
Epidemiological theory of virus variants
Giacomo Cacciapaglia1,2, Corentin Cot1,2, Adele de Hoffer3
1Institut de Physique des 2 Infinis (IP2I) de Lyon, CNRS/IN2P3, UMR5822, 69622 Villeurbanne, France.
Abstract:
We propose a physics-inspired mathematical model underlying the temporal evolution of competing virus variants that relies on the existence of (quasi) fixed points capturing the large time scale invariance of the dynamics. To motivate our result we first modify the time-honoured compartmental models of the SIR type to account for the existence of competing variants and then show how their evolution can be naturally re-phrased in terms of flow equations ending at quasi fixed points. As the natural next step we employ (near) scale invariance to organise the time evolution of the competing variants within the effective description of the epidemic Renormalisation Group framework. We test the resulting theory against the time evolution of COVID-19 virus variants that validate the theory empirically.
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