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Modes of Brain Cell Death Following Intracerebral Hemorrhage

Yan Zhang1,2, Suliman Khan1,2, Yang Liu1,2

  • 1Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Frontiers in Cellular Neuroscience
|February 21, 2022
PubMed

Insights

Intracerebral hemorrhage (ICH) causes cell death, leading to neurological deficits. This review explores ICH-induced cell death pathways and potential treatments targeting these mechanisms.

Area of Science:

  • Neuroscience
  • Pathology
  • Cell Biology

Background:

  • Intracerebral hemorrhage (ICH) is a severe stroke type with high mortality and morbidity.
  • ICH triggers cell death, contributing significantly to neurological deficits.
  • Current therapeutic options for mitigating ICH-induced cell death are limited.

Purpose of the Study:

  • To review and synthesize current knowledge on cell death mechanisms following ICH.
  • To focus on apoptosis and necrosis while exploring newer cell death modalities.
  • To summarize potential treatment strategies targeting specific cell death pathways in ICH.

Main Methods:

  • Literature review of studies on intracerebral hemorrhage and cell death.
  • Analysis of research focusing on apoptosis, necrosis, necroptosis, pyroptosis, ferroptosis, autophagy, and parthanatos in ICH.
  • Synthesis of findings related to therapeutic interventions for ICH-related brain injury.

Main Results:

  • ICH induces various forms of cell death, including classical apoptosis and necrosis.
  • Emerging cell death pathways like necroptosis, pyroptosis, ferroptosis, autophagy, and parthanatos are implicated in ICH.
  • Understanding these pathways offers novel targets for therapeutic development.

Conclusions:

  • ICH pathogenesis involves a complex interplay of diverse cell death mechanisms.
  • Targeting specific cell death pathways presents a promising therapeutic avenue for mitigating brain injury after ICH.
  • Further research is needed to translate these findings into effective clinical treatments.

Keywords:
apoptosisautophagycell deathferroptosisintracerebral hemorrhagenecrosisparthanatos

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