Related Experiment Video
Updated: Oct 3, 2025
07:36
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
11.5K
Preterm Delivery: Microbial Dysbiosis, Gut Inflammation and Hyperpermeability
Silvia Arboleya1, David Rios-Covian2, Flore Maillard2
1IPLA-CSIC, Paseo Río Linares, Villaviciosa, Spain.
Frontiers in Microbiology
|February 21, 2022
Summary
Preterm birth leads to significant neonatal health issues and long-term non-transmissible diseases. Our study in mice reveals higher systemic inflammation and gut permeability in preterm neonates, highlighting the need for new research models.
Area of Science:
- Neonatal Health
- Reproductive Biology
- Gastroenterology
Background:
- Preterm birth is a leading cause of neonatal mortality and morbidity.
- Known risk factors include medical conditions and lifestyle, but molecular mechanisms are unclear.
- Current murine models often focus on inflammation and have limited health readouts.
Purpose of the Study:
- To investigate systemic inflammation and gut permeability in preterm neonates.
- To highlight the need for non-inflammatory murine models for preterm birth research.
- To understand the long-term health consequences of preterm birth.
Main Methods:
- Analysis of SWISS-CD1 mice born prematurely compared to term-born pups.
- Assessment of systemic inflammation and gastrointestinal tract permeability at weaning age.
- Review of recent discoveries and limitations of existing research models.
Main Results:
- Preterm mice exhibited elevated systemic inflammation.
- Preterm mice demonstrated increased gastrointestinal tract permeability.
- These findings suggest a link between preterm birth and gut health issues.
Conclusions:
- Preterm birth is associated with increased systemic inflammation and gut permeability.
- Developing non-inflammatory murine models is crucial for understanding preterm birth phenotypes.
- Further research is needed to design effective strategies for preventing preterm birth sequelae.
Related Concept Videos
01:23Anatomy of the Intestines
83.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
83.8K
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
390
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
390
01:17Irritable Bowel Syndrome I: Introduction
415
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
415
01:30Inflammatory Bowel Disease II: Crohn's Disease
435
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
435
01:17Chronic Bowel Disorders: Introduction
554
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
554
01:05Physiology of Enteric Nervous System and Gut Health
467
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
467