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Recent Applications of Electrospun Nanofibrous Scaffold in Tissue Engineering
Hamza Abu Owida1, Jamal I Al-Nabulsi1, Feras Alnaimat1
1Medical Engineering Department, Faculty of Engineering, Al-Ahliyya Amman University, Amman 19328, Jordan.
Applied Bionics and Biomechanics
|February 21, 2022
Summary
Tissue engineering uses electrospinning to create nanofibrous scaffolds for regenerating tissues like bone, cartilage, and skin. This review covers recent advancements and challenges in tissue regeneration using these engineered structures.
Area of Science:
- Biomedical Engineering
- Materials Science
- Regenerative Medicine
Background:
- Tissue engineering aims to restore tissue function by creating functional constructs.
- Mimicking the extracellular matrix is crucial for engineered tissues.
- Nanostructured scaffolds are vital for oxygen and nutrient transport.
Purpose of the Study:
- To review the application of electrospinning in creating nanofibrous scaffolds for tissue engineering.
- To highlight advancements and challenges in tissue regeneration using electrospun scaffolds.
- To cover applications in bone, cartilage, cardiovascular, and skin tissue regeneration.
Main Methods:
- Electrospinning is utilized to fabricate three-dimensional nanostructures.
- Nanofibrous scaffolds are designed to mimic the natural extracellular matrix.
- Scaffolds facilitate nutrient/oxygen transmission and waste removal.
Main Results:
- Electrospinning has yielded numerous nanofibrous scaffolds for tissue repair.
- These scaffolds show promise for regenerating various tissue types.
- Recent improvements in electrospinning enhance tissue regeneration capabilities.
Conclusions:
- Electrospinning is a key technique in developing advanced tissue-engineered scaffolds.
- Nanofibrous meshes show significant potential for diverse tissue regeneration applications.
- Further research is needed to overcome challenges in clinical translation.
