Related Experiment Video

Updated: Oct 3, 2025

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry
07:20

Measuring Erythrocyte Complement Receptor 1 Using Flow Cytometry

Published on: May 19, 2020

7.3K

Erythrocyte Complement Receptor 1 Gene Polymorphisms and Neonatal Respiratory Distress Syndrome

Walaa Rabie1, Ahmed Al-Taweel1, Walaa A Abuelhamd2

  • 1Department of Clinical and Chemical Pathology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.

Journal of Pediatric Genetics
|February 21, 2022
PubMed

Insights

The erythrocyte complement receptor 1 (ECR1) gene

Area of Science:

  • Genetics
  • Neonatal Medicine
  • Immunology

Background:

  • Respiratory distress syndrome (RDS) is a significant cause of neonatal morbidity.
  • The erythrocyte complement receptor 1 (ECR1) gene plays a role in immune responses.
  • Genetic predisposition to RDS requires further investigation.

Purpose of the Study:

  • To investigate the association between ECR1 gene polymorphisms and the risk of developing RDS.
  • To determine if specific ECR1 gene variants correlate with RDS severity.

Main Methods:

  • Studied 50 infants with RDS and 50 controls.
  • Utilized real-time polymerase chain reaction for allelic discrimination of the A3650G (rs2274567) single nucleotide polymorphism (SNP).
  • Performed genotyping for HindIII restricted ECR1 gene alleles.

Main Results:

  • The L allele of the HindIII restricted SNP was associated with RDS severity.
  • Infants with AA and AG genotypes for the A3650G SNP required longer oxygen and ventilation durations compared to GG genotype (p=0.01 and p=0.03, respectively).

Conclusions:

  • ECR1 gene polymorphisms, specifically A3650G and HindIII digested variants, show a potential association with RDS severity.
  • Further research is needed to fully elucidate the role of ECR1 in RDS pathogenesis.

Keywords:
A3650G SNPEcr1RDSpolymorphism

More Related Videos

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.9K
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

6.5K

Related Concept Videos

Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
2.0K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
1.3K
Translation01:31

Translation

Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
16.1K
Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon...
3.7K
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
35.6K
Common Respiratory Disorders01:31

Common Respiratory Disorders

Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
977