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Characterisation of two unique sesquiterpenoids from Trichoderma hypoxylon
Jinyu Zhang1,2, Wen-Bing Yin1,2
1State Key Laboratory Of Mycology, Institute Of Microbiology, Chinese Academy Of Sciences, Beijing, Republic of China.
Mycology
|February 21, 2022
Summary
Researchers identified two novel sesquiterpenoids from Trichoderma hypoxylon, a fungus. Compound 4 was also newly found in nature, with structures confirmed using advanced spectroscopic techniques.
Area of Science:
- Natural Product Chemistry
- Mycology
- Organic Chemistry
Background:
- Trichoderma species are known sources of bioactive secondary metabolites.
- Fungal natural products are crucial for drug discovery and development.
- Exploring fungal diversity can lead to the discovery of novel chemical entities.
Purpose of the Study:
- To isolate and characterize new chemical compounds from the fungus Trichoderma hypoxylon.
- To investigate the chemical diversity of fungal metabolites.
- To determine the structures and absolute configurations of isolated compounds.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation using High-Resolution Electrospray Ionization Mass Spectrometry (HR-ESI-MS).
- Spectroscopic analysis including 1D and 2D Nuclear Magnetic Resonance (NMR).
- Determination of absolute configurations via Electronic Circular Dichroism (ECD) calculations.
Main Results:
- Two new sesquiterpenoids (compounds 1-2) were isolated and structurally characterized.
- Three known compounds were identified, with compound 4 being isolated from a natural source for the first time.
- The structures and absolute configurations of the new compounds were unambiguously assigned.
Conclusions:
- Trichoderma hypoxylon produces novel sesquiterpenoids.
- The study expands the known chemical repertoire of Trichoderma species.
- The findings contribute to the understanding of fungal secondary metabolism and provide potential leads for future research.
