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Updated: Oct 3, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
Low Bone Mineral Density in Hemophiliacs
Jennifer Gebetsberger1, Michael Schirmer2, Walter J Wurzer3
1Department of Pediatrics I, Medical University of Innsbruck, Innsbruck, Austria.
Objective:
To review the current knowledge on bone health in patients with hemophilia A and the underlying pathogenetic mechanisms.
Data Sources:
Original research articles, meta-analyses, and scientific reviews.
Data Synthesis:
Already in childhood, patients with hemophilia A are prone to low bone mineral density, leading to osteopenia and/or osteoporosis. Initially associated with the life style of hemophilia, today we are faced with accumulating evidence that coagulation factor VIII is involved directly or indirectly in bone physiology.
Conclusion:
Understanding the role of factor VIII and the mechanisms of decreased bone mineral density in hemophilia A is critically important, especially as non-factor replacement therapies are available, and treatment decisions potentially impact bone health.
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