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Role of Mitophagy in Coronary Heart Disease: Targeting the Mitochondrial Dysfunction and Inflammatory Regulation

Mingxuan Liu1, Ying Wu1

  • 1School of Nursing, Capital Medical University, Beijing, China.

Frontiers in Cardiovascular Medicine
|February 21, 2022
PubMed

Insights

Mitochondrial dysfunction and mitophagy disorders are key in coronary heart disease (CHD) pathogenesis. Targeting mitochondrial quality control offers promising therapeutic strategies for treating CHD and its complications like arrhythmia and fibrosis.

Area of Science:

  • Cardiovascular Medicine
  • Cell Biology
  • Mitochondrial Biology

Background:

  • Coronary heart disease (CHD) remains a leading global cause of mortality.
  • While treatments have improved, severe arrhythmia and myocardial fibrosis in later CHD stages require urgent attention.
  • Mitochondria are crucial for cellular energy production and are implicated in myocardial ischemia/hypoxia, arrhythmia, and fibrosis.

Purpose of the Study:

  • To review experimental evidence on the role of mitochondrial homeostasis and quality control in CHD pathogenesis.
  • To summarize current therapeutic drugs targeting mitochondrial function and quality control for CHD.

Main Methods:

  • Literature review of experimental advances in CHD research.
  • Focus on the role of mitochondrial dysfunction and mitophagy in cardiovascular disease.
  • Analysis of regulatory drugs targeting mitochondrial pathways.

Main Results:

  • Mitochondrial dysfunction and mitophagy disorders are significant contributors to CHD.
  • Mitophagy plays a critical role in mediating inflammatory damage and clearing damaged mitochondria in cardiomyocytes and vascular endothelial cells.
  • Evidence supports the importance of maintaining mitochondrial homeostasis and quality control in CHD pathology.

Conclusions:

  • Mitochondrial homeostasis and quality control are vital in the pathological mechanisms of CHD.
  • Targeting mitochondrial function and quality control presents a promising therapeutic avenue for CHD, including managing associated arrhythmia and myocardial fibrosis.

Keywords:
arrhythmiacardiomyocytescoronary heart diseaseinflammationischemia/hypoxiamitochondriamyocardial injuryoxidative stress

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