Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

45.6K
Overview
45.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pyruvylation of STAT1 inhibits anti-viral immunity: Prospects for new anti-viral therapeutics.

Molecular cell·2026
Same author

4-Octyl itaconate blocks STAT3-induced ACE2 expression to reduce uptake of SARS-CoV-2.

Biochemical pharmacology·2026
Same author

Mapping the mammalian dark metabolome by <i>in vivo</i> isotope tracing.

bioRxiv : the preprint server for biology·2026
Same author

Retraction Note: MAVS is a sensor of fumarate during antiviral immunity.

Nature microbiology·2026
Same author

Tofacitinib repairs inflammation and mitochondrial dysregulation in GM-CSF-reprogrammed RA macrophages.

Cellular & molecular immunology·2026
Same author

Mitochondria target the plasma membrane to cause mitoxyperiosis.

Cell research·2026

Related Experiment Video

Updated: Oct 3, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

10.9K

Ironing Out Vaccine Efficacy.

Christian G Peace1, Luke A J O'Neill1

  • 1School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland.

Med (New York, N.Y.)
|February 21, 2022
PubMed
Summary

Iron deficiency weakens immune responses to vaccines. Maintaining adequate serum iron levels is crucial for lymphocyte function, suggesting iron supplementation can enhance vaccine effectiveness, including for COVID-19.

Area of Science:

  • Immunology
  • Nutritional Science
  • Infectious Disease

Background:

  • Iron deficiency is associated with compromised humoral immunity, potentially impacting vaccine efficacy.
  • Lymphocyte function, critical for adaptive immunity, may be modulated by iron status.

Purpose of the Study:

  • To investigate the role of serum iron levels in lymphocyte function during vaccination and infection.
  • To evaluate iron supplementation as a strategy for improving vaccine responses.

Main Methods:

  • Analysis of serum iron levels in relation to immune cell function.
  • Assessment of vaccine efficacy in the context of varying iron status.

Main Results:

  • Serum iron levels significantly influence lymphocyte function.

More Related Videos

In Vitro ELISA Test to Evaluate Rabies Vaccine Potency
09:04

In Vitro ELISA Test to Evaluate Rabies Vaccine Potency

Published on: May 11, 2020

12.8K
Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
06:08

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

1.4K

Related Experiment Videos

Last Updated: Oct 3, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

10.9K
In Vitro ELISA Test to Evaluate Rabies Vaccine Potency
09:04

In Vitro ELISA Test to Evaluate Rabies Vaccine Potency

Published on: May 11, 2020

12.8K
Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
06:08

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

1.4K
  • Adequate iron is essential for optimal immune responses to vaccination and infection.

    • Conclusions:

    • Maintaining sufficient serum iron is vital for robust vaccine efficacy.
    • Iron supplementation emerges as a potential therapeutic strategy to bolster immunity against infectious diseases, including COVID-19.