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Concurrent interactions between prefrontal cortex and hippocampus during a spatial working memory task.

Wei Zhang¹, Lei Guo², Dongzhao Liu²

¹School of Information Engineering, Tianjin University of Commerce, No. 409 Guangrong Rd, Beichen District, Tianjin, 300134, China. zhangwei@tjcu.edu.cn.

Brain Structure & Function

|February 21, 2022

Summary

This study reveals how the hippocampus and prefrontal cortex interact during spatial working memory (SWM) tasks. Findings show theta and gamma oscillations are key, with information flowing from the hippocampus to the prefrontal cortex.

Keywords:

Concurrent interaction Cross-frequency coupling Effective connectivity Functional connectivity Granger causality Spatial working memory

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Area of Science:

Neuroscience
Cognitive Science

Background:

Spatial working memory (SWM) involves temporary manipulation of spatial information.
The hippocampus (HPC) and prefrontal cortex (PFC) are crucial for SWM, but their interaction mechanism is unclear.

Purpose of the Study:

To investigate the interaction between the rat ventral HPC and medial PFC during SWM tasks.
To analyze functional and effective connectivity between HPC and PFC during SWM.

Main Methods:

Simultaneous local field potential (LFP) recordings from rat ventral HPC and medial PFC.
Application of cross-frequency coupling and Granger causality algorithms.
Analysis of concurrent interactions based on functional and effective connectivity.

Main Results:

LFP power in HPC and PFC decreased during learning and peaked before behavioral selection in SWM.
Theta and gamma oscillations were prominent during SWM.
Phase-amplitude coupling between PFC gamma and HPC theta correlated with SWM formation.
Effective connectivity showed greater directed activity transmission from HPC to PFC.

Conclusions:

HPC-PFC interactions are crucial for SWM formation and maintenance.
Theta-gamma phase-amplitude coupling supports concurrent HPC-PFC interactions.
Information flow during SWM is predominantly from the HPC to the PFC.