Experimental functional shift-induced osteoarthritis-like changes at the TMJ and altered integrin expression in a rat
Yuchun Zou1,2, Senxin Cai1,2, Hanyu Lin1,2
1Fujian Key Laboratory of Oral Diseases, School of Stomatology, Fujian Medical University, Fuzhou, China.
Annals of the New York Academy of Sciences
|February 21, 2022
Summary
Mandibular deviation in rats led to temporomandibular joint (TMJ) osteoarthritis-like changes, including cartilage thinning and bone loss. Integrin β family expression changes may be linked to these TMJ disorders.
Area of Science:
- Biomedical Engineering
- Oral and Maxillofacial Surgery
- Orthodontics
Background:
- Mandibular deviation alters the temporomandibular joint (TMJ) biomechanical environment.
- This alteration can lead to cartilage thinning on the affected side.
Purpose of the Study:
- To investigate the impact of experimental mandibular functional deviation on the TMJ.
- To explore the role of integrin β family members in TMJ changes.
Main Methods:
- Utilized a rat model with experimental functional deviation of the mandible.
- Evaluated TMJ changes using histological staining, immunofluorescence, qPCR, and micro-CT over 8 weeks.
Main Results:
- Observed condyle shape changes, cartilage thinning, and increased hypertrophic layer.
- Detected extracellular matrix degradation and subchondral bone loss, indicative of osteoarthritis (OA)-like changes.
- Found altered integrin β family expression, particularly integrin β2, correlating with OA-like changes.
Conclusions:
- Experimental mandibular deviation induces TMJ OA-like changes in rats.
- Integrin β family members, especially β2, may play a role in the development of TMJ OA.
