GABA imbalance in squirrel monkey after unilateral vestibular end-organ ablation

Using an antibody against GABA conjugated to bovine serum albumin, GABA-like immunoreactivity was measured in vestibular nuclei and adjacent structures in normal and unilaterally vestibular-deafferentiated squirrel monkeys. Three and 6 days after end-organ ablation, GABA levels increased in lateral vestibular nucleus (LVN) on the side ipsilateral to the lesion, while GABA decreased in LVN on the side contralateral to the lesion. GABA levels in ventral cochlear nucleus or inferior cerebellar peduncle did not differ from normal in either case.