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Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
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Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

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Biopolymer-Based Multilayer Microparticles for Probiotic Delivery to Colon

Sepehr Talebian1,2, Timothy Schofield1, Peter Valtchev1,3

  • 1School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.

Advanced Healthcare Materials
|February 21, 2022
PubMed

Insights

Multilayer encapsulation using biopolymers enhances probiotic survival during storage and digestion. This advanced technique offers superior protection compared to single-layer methods for improved health benefits.

Area of Science:

  • Food Science
  • Biotechnology
  • Materials Science

Background:

  • Probiotic viability is crucial for health benefits but is compromised during food storage and gastrointestinal transit.
  • Microencapsulation using biopolymers is a key strategy to protect probiotics, but single-layer approaches have limitations.

Purpose of the Study:

  • To review emerging multilayer encapsulation methods for probiotics using biopolymers.
  • To correlate fabrication techniques with microparticle properties and categorize multilayer designs.
  • To examine recent biopolymeric formulations and their performance in animal models.

Main Methods:

  • Review of scientific literature on multilayer microencapsulation of probiotics.
  • Analysis of biopolymer properties and fabrication techniques.
  • Evaluation of physical and biological properties of multilayer microparticles.

Main Results:

  • Multilayer encapsulation significantly improves probiotic resistance to environmental stresses.
  • Different layer designs and fabrication methods yield varied microparticle characteristics.
  • Promising results observed in animal models for gastrointestinal transit and disease.

Conclusions:

  • Multilayer biopolymer encapsulation represents a significant advancement for probiotic delivery.
  • Novel materials and fabrication approaches are emerging for enhanced probiotic protection.
  • This strategy holds potential for realizing the full health benefits of probiotics.
Keywords:
colondrug deliveryhydrogelsmicroencapsulationprobiotics

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