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Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
Synthesis and characterization of epoxide impurities of abiraterone acetate
Seyed Mohammad Hossein Shirazi1, Javad Mokhtari1, Zohreh Mirjafary1
1Department of Chemistry, Science and Research Branch, Islamic Azad University, P.O. Box 14515/775, Tehran, Iran.
Abstract:
Abiraterone acetate is an antiandrogen steroidal drug that is used to treat patients with metastatic prostate cancer. During the process development of abiraterone acetate, two process α and β-epoxy abiraterone acetate related impurities (2 and 3) were observed along with the final API. In the present work we describe the synthesis of these two known impurities using abiraterone acetate in the presence of hydrogen peroxide and acetic acid as oxidizing agent. The structure of these impurities fully characterized by NMR, Mass, CHN and HPLC analysis.
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