Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Therapy for granulomatous angiitis.

E H Koo, E W Massey

    Clinical Neuropharmacology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Diagnosing granulomatous angiitis is challenging due to varied symptoms. Definitive diagnosis requires tissue biopsy before treatment to guide therapy and prevent irreversible neurological damage.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA.

    Cellular and molecular life sciences : CMLS·2017
    Same author

    Pivotal role of the RanBP9-cofilin pathway in Aβ-induced apoptosis and neurodegeneration.

    Cell death and differentiation·2012
    Same author

    Amiodarone offsets the cardioprotective effects of ischaemic preconditioning against ischaemia/reperfusion injury.

    The Journal of international medical research·2006
    Same author

    Sural neuropathy: etiologies and predisposing factors.

    Muscle & nerve·2006
    Same author

    Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624).

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2006
    Same author

    Internal carotid artery dissection in stroke from SCUBA diving: a case report.

    Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2003

    Area of Science:

    • Neurology
    • Immunology
    • Pathology

    Background:

    • Granulomatous angiitis (GA) presents a diagnostic challenge due to its diverse clinical manifestations.
    • Commonly mistaken for progressive multifocal encephalopathy, GA can also mimic mass lesions or dementia.

    Observation:

    • Cerebrospinal fluid (CSF) analysis may show elevated protein or a mononuclear cell response.
    • Cerebral angiography can suggest vasculitis, but a definitive diagnosis relies on tissue biopsy.
    • Leptomeningeal biopsy is crucial for confirming GA before initiating immunosuppressive therapy.

    Findings:

    • Corticosteroids are the primary treatment for GA.
    • Immunosuppressive drugs like cyclophosphamide (cytoxan) may benefit refractory cases, though routine use is unproven.

    Related Experiment Videos

    Implications:

    • Establishing an unequivocal diagnosis is paramount due to the long-term nature of treatment and potential for relapse.
    • Prompt diagnosis and biopsy are essential to guide appropriate, potentially hazardous, immunosuppressive therapies and preserve neurological function.