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Updated: Oct 3, 2025
09:29
Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
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Nucleosides and emerging viruses: A new story
Vincent Roy1, Luigi A Agrofoglio1
1ICOA, University of Orléans, CNRS UMR 7311, Rue de Chartres, 45067 Orléans, France.
Drug Discovery Today
|February 21, 2022
Summary
New ribonucleoside analogs show promise as antiviral drugs targeting viral RNA-dependent RNA polymerase (RdRp). These compounds are crucial for developing new therapies against emerging RNA viruses lacking vaccines or treatments.
Area of Science:
- Virology
- Medicinal Chemistry
Background:
- Nucleoside and nucleotide analogs are key antiviral therapies for herpesviruses, HIV, and hepatitis viruses.
- Emerging RNA viruses, unlike SARS-CoV-2, currently lack vaccines and effective small antiviral drugs.
Purpose of the Study:
- To provide an overview of recently developed ribonucleoside analogs.
- To highlight their role as inhibitors of viral RNA-dependent RNA polymerase (RdRp).
Main Methods:
- Literature review of recent advancements in ribonucleoside analog development.
- Analysis of structure-activity relationships for RdRp inhibition.
Main Results:
- Several novel ribonucleoside analogs have been identified.
- These analogs demonstrate inhibitory activity against viral RdRp.
Conclusions:
- Developed ribonucleoside analogs represent promising lead structures for new antiviral drug discovery.
- These compounds offer potential therapeutic strategies against emerging RNA viruses.
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