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Updated: Oct 3, 2025

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
Spontaneous regressions in non-small cell lung cancer with different clinical outcomes
Masaki Yamamoto1, Shuhei Iizuka1, Yoshiro Otsuki2
1Department of General Thoracic Surgery, Seirei Hamamatsu General Hospital, 2-12-12, Sumiyoshi, Nakaku, Hamamatsu-city, Shizuoka 430-8558, Japan.
Introduction And Importance:
Spontaneous regression (SR) of cancer is extremely rare in non-small cell lung cancer and the exact pathogenesis is unclear.
Case Presentations:
A 69-year-old man underwent a right upper lobectomy for a squamous cell carcinoma histologically confirmed 8 weeks prior. A histopathological examination of the surgical specimen revealed no viable cancer. He remains disease free at 5 years after surgery. A 77-year-old man presented with a metastatic bone tumor compatible with a non-small cell lung cancer origin. He had undergone a surgical biopsy for a right lung nodule of which the histopathological examination revealed only scar tissue a year prior. He died of cancer 4 months after the diagnosis of a bone metastasis.
Clinical Discussion:
The unknown etiology of an SR of cancer is still to be resolved.
Conclusion:
Patients with an SR of cancer may yield a variety of clinical outcomes and a meticulous observation is essential.
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