Related Experiment Video
Updated: Oct 3, 2025
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
Published on: April 13, 2015
Angiographic predictors of coronary hemodynamics
Daniel Nour1, Usaid Allahwala1, Peter Hansen1
1Department of Cardiology, Royal North Shore Hospital, North Sydney, Sydney.
Insights
Fractional flow reserve (FFR) is linked to diameter stenosis but not lesion length or location in coronary artery disease. Left anterior descending artery lesions showed significantly lower FFR.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Diagnostic Imaging
Background:
- Fractional flow reserve (FFR) is crucial for assessing the hemodynamic significance of coronary artery stenoses.
- Quantitative coronary analysis (QCA) provides detailed lesion characteristics, but its correlation with FFR requires further investigation.
Purpose of the Study:
- To evaluate the relationship between quantitative lesion parameters (diameter stenosis, length, location, diffuse disease) and FFR in stable coronary artery disease.
- To determine if specific lesion characteristics predict FFR values.
Main Methods:
- Quantitative coronary analysis (QCA) was performed on 384 coronary lesions from patients with stable coronary artery disease undergoing FFR assessment.
- Lesion characteristics including diameter stenosis, length, location (proximal, mid, distal), and diffuse disease were analyzed.
- Statistical correlation was assessed between these QCA parameters and the measured FFR values.
Main Results:
- Diameter stenosis showed a significant correlation with lower FFR (p < 0.005).
- Lesion length, lesion location, and the number of proximal side branches were not associated with FFR.
- Vessels with diffuse disease exhibited a trend towards lower FFR, though not statistically significant (p = 0.375).
- Left anterior descending (LAD) artery lesions had significantly lower FFR compared to non-LAD lesions (p < 0.001).
Conclusions:
- FFR is significantly influenced by diameter stenosis and the location of the lesion, particularly in the LAD.
- Lesion length and diffuse disease characteristics do not appear to be independent predictors of FFR.
- These findings highlight the importance of considering lesion severity and anatomical location when interpreting FFR values.
Abstract:
Aims: Assess the correlation between diameter stenosis, lesion length, location, diffuse coronary disease and with fractional flow reserve (FFR). Methods/Results: We performed quantitative coronary analysis analysis on 384 lesions with stable coronary artery disease undergoing FFR assessment. Vessels were 59.1% left anterior descending artery (LAD), 16.1% left circumflex artery and 14.8% right coronary artery. Median diameter stenosis was 58% ± 2.5 and median lesion length was 10 mm ± 7.36. 21% of vessels were diffusely diseased. Lesions were 33.6% proximal, 44% mid-vessel and 12% distal. Median FFR was 0.85. Diameter stenosis correlated with lower FFR (p < 0.005, odds ratio [OR]: 2.4 [95% CI: 0.99-5.63]). There was no association between lesion length, location, number of proximal side branches and FFR. Vessels with diffuse disease had a nonsignificant trend for lower FFR (0.84 vs 0.85, p = 0.375, OR: 1.26 [95% CI: 0.76-2.09]). LAD lesions had significantly lower FFR compared with non-LAD (p < 0.001, OR: 2.55 [95% CI: 1.61-4.04]); including left circumflex artery and right coronary artery lesions (p = 0.001, OR: 3.4 [95% CI: 1.7-6.9]) and p = 0.02, OR: 2.55 [95% CI: 1.17-4.34]). Conclusion: FFR is not related to lesion length, location or number of proximal branches.
More Related Videos
Related Concept Videos
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT