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Expression of cold-inducible RNA binding protein in psoriasis
Heba Bazid1, Mohamed Shoeib2, Asmaa Elsayed3
1Dermatology and Andrology Department, Faculty of Medicine, Menoufia University.
Journal of Immunoassay & Immunochemistry
|February 22, 2022
Summary
This study found that cold-inducible RNA binding protein (CIRP) levels are higher in the serum of psoriasis patients but lower in lesional skin compared to controls. This suggests CIRP plays a complex role in psoriasis pathogenesis.
Area of Science:
- Immunodermatology
- Molecular biology
- Biochemistry
Background:
- Psoriasis is a chronic immune-mediated skin condition.
- Cold-inducible RNA binding protein (CIRP) is involved in cellular stress, inflammation, and cancer.
- The role of CIRP in psoriasis is not well understood.
Purpose of the Study:
- To investigate the expression of CIRP in both serum and skin tissue of psoriasis patients.
- To correlate CIRP expression levels with clinical and pathological features of psoriasis.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure serum CIRP levels.
- Immunohistochemistry was employed to detect CIRP expression in skin biopsies.
- Comparison was made between 20 psoriasis patients and 20 healthy controls.
Main Results:
- CIRP was detected in the epidermis of all subjects with nuclear localization.
- Epidermal CIRP expression was significantly lower in lesional and perilesional skin of psoriasis patients compared to controls.
- Serum CIRP levels were significantly elevated in psoriasis patients compared to healthy individuals.
Conclusions:
- CIRP exhibits differential expression in serum and lesional skin in psoriasis patients.
- The distinct intracellular and extracellular expression patterns suggest a complex and potentially dual role for CIRP in psoriasis.
- Further research is warranted to elucidate the specific functions of CIRP in the pathogenesis of psoriasis.
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