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The Antibacterial Activity of Natural-derived Flavonoids
Zhenyou Tan1, Jun Deng2, Qiongxian Ye2
1Guangdong Xianqiang Pharmaceutical Co., Ltd, Guangzhou, P.R. China.
Current Topics in Medicinal Chemistry
|February 22, 2022
Summary
Natural flavonoids show significant antibacterial potential by disrupting bacterial cell membranes and metabolic processes. This review highlights recent research on these plant-derived compounds as novel antibacterial agents.
Area of Science:
- Phytochemistry
- Microbiology
- Pharmacology
Background:
- Flavonoids are diverse phenolic compounds abundant in plants.
- They possess inherent antibacterial properties, acting through various mechanisms.
- Natural products are a key source for novel therapeutic agents.
Purpose of the Study:
- To review recent advancements in natural-derived flavonoids with antibacterial potential.
- To identify novel antibacterial lead compounds and candidates from plant sources.
- To cover research published between January 2016 and July 2021.
Main Methods:
- Comprehensive literature search for relevant studies.
- Analysis of research on natural flavonoids and their glycosides.
- Focus on studies reporting antibacterial activity and mechanisms.
Main Results:
- Numerous natural flavonoids and flavonoid glycosides exhibit potent antibacterial activity.
- Key mechanisms include cytoplasmic membrane damage, energy metabolism inhibition, and nucleic acid synthesis interference.
- Recent studies have identified promising flavonoid-based antibacterial candidates.
Conclusions:
- Natural-derived flavonoids represent a valuable resource for developing new antibacterial drugs.
- Further research can optimize these compounds for therapeutic applications.
- Flavonoids offer a promising strategy to combat antibiotic resistance.
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