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Published on: June 2, 2022
Sortilin, carbamylation, and cardiovascular calcification in chronic kidney disease
Ziad A Massy1, Sophie Liabeuf2
1Department of Nephrology, Ambroise Paré University Medical Center, Assistance Publique - Hôpitaux de Paris, Boulogne-Billancourt/Paris, France; Inserm 1018 Team5, Université Paris-Saclay, Université Versailles Saint-Quentin-en-Yvelines, Inserm, Clinical Epidemiology Team, Centre de Recherche en Epidémiologie et Santé des Populations, Villejuif, France.
Abstract:
Sortilin appears to play important roles in the pathogenesis of vascular and metabolic diseases, such as cardiovascular calcification. Post-translational modifications of sortilin (i.e., phosphorylation or carbamylation) are among the key mechanisms of its actions. Recent data extended the role of carbamylated sortilin to the pathogenesis of cardiovascular calcifications in chronic kidney disease. Whether therapeutic tools potentially available to inhibit the carbamylation process in chronic kidney disease patients would allow preventing cardiovascular calcifications remains to be demonstrated.
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