[Effect of group B vitamins on 35S-lipoic acid intake by mouse tissues]

Lipoic acid intake following parenteral administration with functionally linked vitamins depends on molar relations between them. It is shown that a combined administration of 35S-lipoate with these vitamins decreases radioactivity 30-120 min after the injection in most of tissues as compared to the control, except for the liver where it does not change or increases (60 min after administration in combination with thiamin or pantothenate). Following 18h thiamin and mixture of vitamins induce an intensified intake of labelled lipoic acid by the brain tissue, a 4-fold increase in case of thiamin and a 2.6-fold increase in case of the vitamins mixture.