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Alterations of CD163 expression in the complications of diabetes: A systematic review

Elisha Siwan1, Stephen M Twigg2, Danqing Min2

  • 1Greg Brown Diabetes and Endocrinology Research Laboratory, Sydney Medical School (Central), Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Australia.

Journal of Diabetes and Its Complications
|February 22, 2022
PubMed
Abstract

Insights

Soluble CD163 levels increase with diabetes complications, suggesting its role as an inflammation biomarker. Further research is needed to understand CD163

Area of Science:

  • Immunology
  • Endocrinology
  • Molecular Biology

Background:

  • Diabetes mellitus is characterized by chronic inflammation.
  • Scavenger receptor CD163, an anti-inflammatory marker on macrophages, is linked to diabetes complications.

Purpose of the Study:

  • To systematically review human studies on CD163 expression in diabetes complications.
  • To investigate CD163's potential as a biomarker and mediator in diabetes progression.

Main Methods:

  • Systematic literature search of Scopus, Embase, and Medline databases.
  • Inclusion of 11 studies with 821 participants following PRISMA guidelines.
  • Quantification of CD163 via soluble, cell surface, and mRNA measures.

Main Results:

  • Soluble CD163 (sCD163) was upregulated in plasma/serum and local body fluids of patients with diabetes complications.
  • sCD163 is implicated in the progression of diabetes complications.
  • CD163+ cells and mRNA expression showed variable patterns across complications.

Conclusions:

  • Altered CD163 expression is observed in various diabetes complications.
  • Circulating sCD163 shows potential as an inflammation biomarker for diabetes.
  • Further investigation into variable CD163 cell surface and mRNA expression is warranted.
Keywords:
BiomarkerCD163Diabetes complicationsInflammationMacrophagesMonocytes

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