Related Experiment Video

Updated: Oct 3, 2025

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

15.1K

Coronary volume to left ventricular mass ratio in patients with diabetes mellitus

Jurrien H Kuneman1, Mohammed El Mahdiui1, Alexander R van Rosendael1

  • 1Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.

Journal of Cardiovascular Computed Tomography
|February 22, 2022
PubMed

Insights

Diabetic patients have a significantly lower coronary volume to left ventricular mass (V/M) ratio, indicating potential vascular imbalance. This finding persists even when accounting for coronary artery disease severity, suggesting diabetes impacts coronary vasculature independently.

Area of Science:

  • Cardiology
  • Diabetology
  • Medical Imaging

Background:

  • Diabetes mellitus is a significant risk factor for coronary artery disease (CAD).
  • The coronary volume to left ventricular mass (V/M) ratio is an emerging parameter assessing the balance between coronary vasculature and myocardial mass.
  • Understanding V/M ratio in diabetic patients is crucial for evaluating CAD risk.

Purpose of the Study:

  • To investigate the V/M ratio derived from coronary computed tomography angiography (CCTA) in patients with diabetes.
  • To compare the V/M ratio between diabetic and non-diabetic individuals.

Main Methods:

  • Utilized data from the ADVANCE registry, including patients with suspected CAD and known diabetic status.
  • Analyzed coronary artery volume and left ventricular myocardial mass from CCTA.
  • Calculated and compared the V/M ratio between diabetic and non-diabetic patient groups.

Main Results:

  • Patients with diabetes had a significantly lower coronary volume (2850 mm³ vs. 3040 mm³) but comparable myocardial mass (122 g vs. 122 g) compared to non-diabetics.
  • The V/M ratio was significantly lower in diabetic patients (23.9 mm³/g vs. 25.7 mm³/g).
  • This reduction in V/M ratio was observed in both obstructive and non-obstructive CAD subgroups among diabetic patients.

Conclusions:

  • Diabetic patients exhibit a significantly reduced V/M ratio compared to non-diabetic individuals.
  • The lower V/M ratio in diabetes is evident even after adjusting for obstructive coronary stenosis.
  • Further research is warranted to determine the clinical significance of this reduced V/M ratio in diabetic patients.
Abstract

Keywords:
Coronary artery diseaseCoronary computed tomography angiographyCoronary volumeDiabetes mellitusLeft ventricular massVolume to mass ratio

More Related Videos

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism11:04

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

11.3K
Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

788

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.5K
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.6K
Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
1.7K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.1K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
70
Cardiac Output and Stroke Volume01:11

Cardiac Output and Stroke Volume

Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
In an average resting adult male, the typical cardiac...
3.5K