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Updated: Aug 8, 2026

Microinjection Method for Anopheles gambiae Embryos
Published on: July 7, 2021
Transmission-blocking drugs for malaria elimination
Lyn-Marié Birkholtz1, Pietro Alano2, Didier Leroy3
1Department of Biochemistry, Genetics, and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Pretoria, South Africa.
Abstract:
Preventing human-to-mosquito transmission of malaria parasites provides possible solutions to interrupt the malaria parasite life cycle for malaria elimination. The development of validated routine assays enabled the discovery of such transmission-blocking compounds. Currently, one development priority remains on combinations of dual-active compounds with equipotent activity against both the disease-causing asexual and transmissible, sexual erythrocytic stages. Additionally, transmission-blocking compounds that target gametocyte-specific biology could be used in combination with compounds against asexual parasites. In either case, preventing transmission will reduce the risk of reinfection and, if different processes are targeted, also curb the spread of drug resistance. Here, we provide an updated roadmap to the discovery and development of new antimalarials with transmission-blocking activity to guide drug discovery for malaria elimination.
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