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Corneal hysteresis: ready for prime time?

Alessandro A Jammal¹, Felipe A Medeiros^1,2

¹Duke Eye Center and Department of Ophthalmology.

Current Opinion in Ophthalmology

|February 22, 2022

Summary

Corneal hysteresis, a measure of corneal biomechanics, is a strong predictor of glaucoma development and progression. Measuring corneal hysteresis is recommended for glaucoma risk assessment and patient management.

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Area of Science:

Ophthalmology
Biomechanics
Glaucoma Research

Background:

Corneal hysteresis (CH) reflects the cornea's ability to dissipate energy.
CH measurements are clinically accessible and may indicate posterior ocular tissue biomechanics.
These biomechanical properties are potentially linked to glaucoma susceptibility.

Purpose of the Study:

To review recent findings on corneal hysteresis in relation to glaucoma.
To evaluate CH as a surrogate marker for posterior ocular biomechanics.
To assess the predictive value of CH for glaucoma development and progression.

Main Methods:

Review of recent clinical studies and evidence.
Analysis of associations between CH and glaucoma outcomes.

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Comparison of CH with corneal thickness and conventional tonometry.

Main Results:

CH is predictive of glaucoma development in at-risk eyes.
Lower CH is associated with increased glaucoma progression and visual field loss.
CH appears to be a stronger predictor than corneal thickness.
Corneal-corrected intraocular pressure measurements show promise.

Conclusions:

Corneal hysteresis is a significant risk factor for glaucoma.
Clinicians should measure CH in patients at risk for or diagnosed with glaucoma.
CH measurement aids in glaucoma risk assessment and management.