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Positive Association between the Triglyceride-Glucose Index and Hyperuricemia in Chinese Adults with Hypertension: An

Chao Yu1,2,3, Tao Wang1,2,3, Wei Zhou1,2,3

  • 1Center for Prevention and Treatment of Cardiovascular Diseases, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

International Journal of Endocrinology
|February 22, 2022
PubMed

Insights

The triglyceride-glucose (TyG) index is linked to higher hyperuricemia risk in Chinese adults with hypertension. Higher TyG index levels significantly increase the likelihood of developing hyperuricemia.

Area of Science:

  • Cardiovascular Research
  • Metabolic Syndrome Studies
  • Hypertension Research

Background:

  • Previous research indicates a link between the triglyceride-glucose (TyG) index and hyperuricemia in the general population.
  • The relationship between the TyG index and hyperuricemia specifically within hypertensive patient cohorts remains under-investigated.
  • This study addresses this gap by examining the association in adult Chinese hypertensive patients.

Purpose of the Study:

  • To investigate the relationship between the TyG index and hyperuricemia.
  • To assess the TyG index as a potential indicator for hyperuricemia risk in hypertensive adults.
  • To provide insights into metabolic derangements associated with hypertension and hyperuricemia.

Main Methods:

  • A real-world observational study involving 13,060 adult Chinese hypertensive patients.
  • The triglyceride-glucose (TyG) index was calculated using fasting triglyceride and glucose levels.
  • Hyperuricemia was defined as serum uric acid concentration ≥420 µmol/L (7 mg/dL).

Main Results:

  • A positive correlation was observed between the TyG index and serum uric acid levels (β = 38.03).
  • The TyG index showed a significant positive association with hyperuricemia (OR = 2.04).
  • Increased TyG index quartiles were associated with progressively higher risks of hyperuricemia, with the highest quartile showing a 2.79-fold increased risk.

Conclusions:

  • The triglyceride-glucose (TyG) index is positively associated with serum uric acid and hyperuricemia in hypertensive adults.
  • The TyG index may serve as a valuable biomarker for predicting hyperuricemia risk in this population.
  • Findings highlight the interplay between metabolic factors and hyperuricemia in hypertension.
Abstract

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