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Guillain-Barre Syndrome After Two COVID-19 Vaccinations: Two Case Reports With Follow-up Electrodiagnostic Study
Jun Woo Kim1, Yong Gyun Kim1, Yu Chan Park1
1Department of Rehabilitation Medicine, Hanyang University College of Medicine, Seoul, Korea.
Journal of Korean Medical Science
|February 22, 2022
Summary
Two Korean patients developed Guillain-Barre syndrome (GBS), a rare neurological disorder, after COVID-19 vaccination. Both recovered with treatment, highlighting the importance of monitoring GBS post-vaccination.
Area of Science:
- Neurology
- Immunology
- Infectious Diseases
Background:
- Guillain-Barre syndrome (GBS) is an immune-mediated polyradiculoneuropathy.
- GBS can occur after infections or vaccinations.
- Recent reports link GBS to COVID-19 infection and vaccination.
Observation:
- Two Korean patients, a 42-year-old male and a 48-year-old female, presented with tetraplegia.
- Symptoms appeared within four weeks after receiving different COVID-19 vaccines (AstraZeneca and Pfizer).
Findings:
- Diagnosis confirmed via clinical examination, electromyography, and laboratory tests.
- Both patients showed improvement with intravenous immunoglobulin therapy and rehabilitation.
- Electrodiagnostic follow-up studies were conducted to analyze unique case characteristics.
Implications:
- These cases contribute to the understanding of GBS following COVID-19 vaccination.
- Highlights the need for vigilance and further research into GBS risk after vaccination.
- Emphasizes the effectiveness of current treatments for vaccine-associated GBS.
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