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Multimorbidity patterns and association with mortality in 0.5 million Chinese adults

Junning Fan1, Zhijia Sun1, Canqing Yu1,2

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.

Chinese Medical Journal
|February 22, 2022
PubMed

Insights

Cardiometabolic and respiratory multimorbidity significantly increase mortality risk in Chinese adults. Each additional chronic disease further elevates this risk, highlighting the need for targeted interventions.

Area of Science:

  • Public Health
  • Epidemiology
  • Gerontology

Background:

  • Limited research exists on multimorbidity patterns and mortality in China.
  • Understanding these patterns is crucial for public health strategies in aging populations.

Purpose of the Study:

  • To identify multimorbidity patterns in Chinese adults.
  • To examine the association between these patterns, disease count, and mortality risk.

Main Methods:

  • Utilized data from 512,723 participants (aged 30-79) in the China Kadoorie Biobank.
  • Defined multimorbidity as ≥2 of 15 chronic diseases.
  • Employed hierarchical cluster analysis for pattern identification and Cox regression for mortality analysis.

Main Results:

  • 15.8% of participants had multimorbidity, increasing with age and urban residence.
  • Identified four patterns: cardiometabolic, respiratory, gastrointestinal/hepatorenal, and mental/arthritis.
  • Cardiometabolic (HR=2.20) and respiratory (HR=2.13) multimorbidity showed the highest mortality risks. Each additional disease increased mortality risk by 36%.

Conclusions:

  • Cardiometabolic and respiratory multimorbidity patterns present the greatest mortality risks in Chinese adults.
  • These findings underscore the importance of focused attention and interventions for these specific conditions.
Abstract

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