Straightforward Synthesis of α-Chloromethylketimines Catalyzed by Gold(I). A Clean Way to Building Blocks
Jeymy T Sarmiento1, María Cárcel1, Carmen Ramírez de Arellano1
1Departamento de Química Orgánica, Universidad de Valencia, Av. Vicente Andrés Estellés S/N, 46100 Burjassot, Spain.
Abstract:
α-Chloromethylketimines have been obtained through a gold-catalyzed hydroamination of aromatic and aliphatic 1-chloroalkynes with aromatic amines by using equimolar amounts of both reagents. This procedure has allowed the preparation and spectroscopic characterization of α-chloromethylketimines for the first time with a high degree of purity, complete conversion, and atom economy. The synthetic usefulness of the methodology has been demonstrated with the preparation of β-chloroamines and indoles.
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