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Reconstitution Of β-catenin Degradation In Xenopus Egg Extract
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Closing the gap: Tricellulin/α-catenin interaction maintains epithelial integrity at vertices
Lotte van den Goor1, Ann L Miller1
1Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI.
The Journal of Cell Biology
|February 22, 2022
Abstract:
Tricellular junctions play a critical role in regulating epithelial barrier function. In this issue, Cho et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202009037) demonstrate a novel interaction between tricellulin and α-catenin, which connects tricellular junctions to the actomyosin cytoskeleton, thus supporting the epithelial barrier at cell vertices.
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