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Related Experiment Video

Updated: Oct 2, 2025

Eye Movement Monitoring of Memory
08:06

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Published on: August 15, 2010

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Memory-Assisted Global Impression of Change (MAGIC).

Linda S Deal1, David A Andrae2, Daniela E Myers3

  • 1Pfizer Inc, 235 East 42nd St, New York, NY, 10017, USA. linda_deal@yahoo.com.

Therapeutic Innovation & Regulatory Science
|February 22, 2022
PubMed
Summary
This summary is machine-generated.

Memory assistance for Parkinson's disease patients did not significantly alter patient global impression scores. This suggests the Patient Global Impression of Change (PGIC) and Patient Global Impression Static (PGIS) scales are reliable for assessing patient experience.

Keywords:
Anchor-basedMeaningful within-person changeParkinson’s diseasePatient global impression of changePatient global impression static item

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Area of Science:

  • Clinical Research
  • Patient-Reported Outcomes
  • Neurology

Background:

  • The US FDA is developing guidance for collecting patient experience data.
  • Concerns exist regarding recall error in global impression scales for measuring treatment benefit.
  • This study investigated memory assistance's impact on patient responses in Parkinson's disease.

Purpose of the Study:

  • To assess if memory aids reduce recall bias in patient-reported outcomes for Parkinson's disease.
  • To evaluate the reliability of Patient Global Impression of Change (PGIC) and Patient Global Impression Static (PGIS) scales.
  • To determine if memory assistance impacts the estimation of meaningful within-person change thresholds.

Main Methods:

  • A secondary analysis of a 28-day study in Parkinson's disease patients.
  • Participants used voice recordings as memory aids for baseline status.
  • Patient Global Impression of Change (PGIC) and Static (PGIS) scores were compared before and after memory assistance.

Main Results:

  • High correlations were found between standard and memory-assisted scores (PGIS/MAGIS: ρ=0.88; PGIC/MAGIC: ρ=0.86).
  • Intraclass correlation coefficients (ICC) exceeded the acceptability criterion (≥0.70) for both scales.
  • Memory assistance did not substantially alter the final PGIS/PGIC scores.

Conclusions:

  • The MAGIS/MAGIC methodology using memory assistance is feasible in Parkinson's disease research.
  • Memory assistance does not significantly impact Patient Global Impression of Change (PGIC) and Static (PGIS) scores.
  • These findings support the reliability of PGIC and PGIS scales in capturing patient perspectives.