Related Experiment Video

Updated: Oct 2, 2025

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic
09:03

Nasal Brushing Sampling and Processing Using Digital High Speed Ciliary Videomicroscopy – Adaptation for the COVID-19 Pandemic

Published on: November 7, 2020

5.0K

COVID-19 disease characteristics in different pediatric age groups

Eda Kepenekli1, Nurhayat Yakut2, Zeynep Ergenc2

  • 1Marmara University School of Medicine, Pendik Training and Research Hospital. Department of Pediatrics, Division of Pediatric Infectious Diseases, Istanbul, Turkey. ekepenekli@yahoo.com.

Journal of Infection in Developing Countries
|February 22, 2022
PubMed

Insights

COVID-19 in children presents differently across age groups, with younger children experiencing more fever and laboratory differences. These findings highlight age-variable disease pathogenesis in pediatric coronavirus disease 2019.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Clinical Medicine

Background:

  • Limited understanding of COVID-19 disease characteristics in pediatric populations.
  • Need for age-specific data on pediatric coronavirus disease 2019.
  • Variability in disease presentation across different pediatric age groups.

Purpose of the Study:

  • To investigate and compare COVID-19 disease characteristics in distinct pediatric age groups.
  • To identify age-related differences in clinical symptoms and laboratory findings of pediatric COVID-19.
  • To contribute to understanding the age-dependent pathogenesis of coronavirus disease 2019 in children.

Main Methods:

  • Retrospective, single-center study of 139 pediatric COVID-19 patients.
  • Patients categorized into three age groups: 15 days-24 months (Group 1), 25-144 months (Group 2), and 145-210 months (Group 3).
  • Analysis of clinical symptoms, hospitalization rates, chest X-ray (CXR) scores, and laboratory parameters.

Main Results:

  • Common symptoms included cough (55.4%) and fever (51.8%).
  • Fever was more frequent in Group 1; chest pain was more frequent in Group 3.
  • Group 1 showed higher WBC, lymphocyte, and thrombocyte counts, with altered levels of AST, LDH, D-dimer, Troponin T, hemoglobin, total protein, and albumin compared to other groups.

Conclusions:

  • Pediatric COVID-19 is generally less severe than in adults.
  • Significant clinical and laboratory differences exist between pediatric age groups.
  • These variations support the concept of age-dependent disease pathogenesis in pediatric coronavirus disease 2019.
Abstract

Keywords:
COVID-19ChildrenTurkeypediatric age groups

More Related Videos

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.4K
Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine06:09

Author Spotlight: Exploring Venous Waveforms in Porcine Models to Tackle Volume Overload in Medicine

Published on: January 12, 2024

745

Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
662
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
883
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
377
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
509
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.2K
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.0K