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Related Experiment Video

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Development of an In Vitro Ocular Platform to Test Contact Lenses
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Contact Lenses for Ocular Surface Disease.

Xueyang Wang1, Deborah S Jacobs

  • 1Department of Ophthalmology, Harvard Medical School, Boston, MA.

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|February 22, 2022
PubMed
Summary
This summary is machine-generated.

Therapeutic contact lenses, including bandage soft contact lenses (BSCL) and scleral lenses, can effectively manage ocular surface diseases like graft-vs-host disease and Stevens-Johnson syndrome, despite conventional beliefs. This review highlights their utility and fitting considerations.

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Area of Science:

  • Ophthalmology
  • Biomaterials Science

Background:

  • Ocular surface diseases cause significant patient discomfort and vision loss.
  • Therapeutic contact lenses are underutilized due to misconceptions about their use in compromised ocular environments.
  • Conditions like ocular graft-vs-host disease and Stevens-Johnson syndrome present unique management challenges.

Purpose of the Study:

  • To review the literature on therapeutic contact lenses for ocular surface disease management.
  • To explore the application of bandage soft contact lenses (BSCL), scleral lenses, and prosthetic devices.
  • To provide clinical insights into fitting these specialized lenses.

Main Methods:

  • Focused literature review of studies on BSCLs, scleral lenses, and prosthetic devices.
  • Examination of evidence for recurrent corneal erosion, ocular graft-vs-host disease, and Stevens-Johnson syndrome.
  • Inclusion of clinical pearls for BSCL fitting and antibiotic prophylaxis considerations.

Main Results:

  • Substantial literature supports the use of BSCLs for recurrent corneal erosion.
  • Scleral lenses and prosthetic replacement of the ocular surface ecosystem (PROSE) are effective in managing Stevens-Johnson syndrome.
  • Clinical guidelines and fitting strategies for BSCLs are discussed.

Conclusions:

  • Therapeutic contact lenses, including BSCLs and scleral lenses, are valuable tools for managing complex ocular surface diseases.
  • Addressing conventional wisdom regarding contact lens wear in dry or irritated eyes is crucial for patient care.
  • Further consideration of fitting techniques and prophylactic measures can optimize treatment outcomes.