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Electrical activity can spontaneously arise in coupled passive cells, even without specialized pacemaker cells. This study reveals emergent simplicity and synchronized oscillations in large, spatially extended systems.

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Area of Science:

  • Physiology
  • Theoretical Biology
  • Computational Neuroscience

Background:

  • Spontaneous electrical activity is crucial for physiological processes.
  • This activity can occur even without identified specialized pacemaker cells.
  • Coupled excitable and passive cells may generate periodic oscillations.

Purpose of the Study:

  • Investigate the dynamics of coupled excitable and passive cell assemblies.
  • Explore mechanisms for spontaneous electrical activity emergence.
  • Analyze collective dynamics in large, spatially extended systems.

Main Methods:

  • Studied simple motifs of coupled electrically active and passive cells.
  • Analyzed dynamics including chaos and spatiotemporal patterns.
  • Developed a reduced model with excitatory and oscillatory elements.

Main Results:

  • Observed a wide range of dynamical phenomena, including chaos.
  • Found that lattice embedding yields quiescent or synchronized oscillations.
  • Demonstrated pattern reproduction by a reduced model.

Conclusions:

  • Large, spatially extended systems exhibit emergent simplicity in collective dynamics.
  • Periodic activity can emerge in heterogeneous systems of nonoscillatory elements via diffusive coupling.
  • Dissimilar steady states in isolated elements facilitate emergent periodic activity.