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Related Concept Videos

Ribozymes02:47

Ribozymes

12.7K
The term ribozyme is used for RNA that can act as an enzyme. Ribozymes are mainly found in selected viruses, bacteria, plant organelles, and lower eukaryotes. Ribozymes were first discovered in 1982 when Tom Cech’s laboratory observed Group I introns acting as enzymes. This was shortly followed by the discovery of another ribozyme, Ribonulcease P, by Sid Altman’s laboratory. Both Cech and Altman received the Nobel Prize in chemistry in 1989 for their work on ribozymes.
Ribozymes can...
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Introduction to Enzymes01:22

Introduction to Enzymes

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The use of enzymes by humans dates to 7000 BCE. Humans first used enzymes to ferment sugars and produce alcohol without knowing that this was an enzyme-catalyzed reaction. Wilhelm Kuhne coined the term 'enzyme' in 1877 from the Greek words ‘en’ meaning ‘in’ or ‘within’ and ‘zyme’ meaning ‘yeast.’
Most enzymes are proteins that speed up biochemical reactions without being consumed. Enzymes contain one or more active sites that...
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Related Experiment Video

Updated: Oct 2, 2025

Nanosensors to Detect Protease Activity In Vivo for Noninvasive Diagnostics
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Nanozymes-recent development and biomedical applications.

Xiangyi Ren1, Dongxu Chen2, Yan Wang1

  • 1Core Facilities of West China Hospital, Sichuan University, Chengdu, 610041, China.

Journal of Nanobiotechnology
|February 23, 2022
PubMed
Summary

Nanozymes are nanomaterials with enzyme-like properties, offering stable and cost-effective alternatives in biomedicine. This review explores their mechanisms, applications, and future potential in the biomedical field.

Keywords:
Disease therapyNanozymeOxidative stressReactive oxygen species

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Nanozymes are nanomaterials exhibiting enzyme-mimetic catalytic activities.
  • They offer advantages over natural enzymes, including enhanced stability and lower cost.
  • Their enzyme-like activities are tunable by factors like metal ion state, pH, H2O2, and GSH levels.

Purpose of the Study:

  • To provide a comprehensive review of nanozymes and their biomedical applications.
  • To promote understanding of nanozyme mechanisms and facilitate the development of novel multifunctional nanozymes.
  • To discuss current challenges and future prospects for nanozymes in biomedical research.

Main Methods:

  • Literature review of nanozyme research in the biomedical field.
  • Overview of nanozyme properties and enzyme-like activities.
  • Discussion of nanozyme mechanisms, applications, challenges, and future directions.

Main Results:

  • Nanozymes possess versatile enzyme-like properties with significant biomedical potential.
  • Multi-functional nanozymes have been developed for diverse biomedical applications over the past decade.
  • Understanding nanozyme regulation mechanisms is key to advancing their use.

Conclusions:

  • Nanozymes represent a promising class of materials for advanced biomedical applications.
  • Further research into nanozyme mechanisms and functionalities is warranted.
  • Addressing current challenges will unlock the full potential of nanozymes in the biomedical frontier.