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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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B Cell Activation and Differentiation01:24

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
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Alternative RNA Splicing02:18

Alternative RNA Splicing

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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Updated: Oct 2, 2025

Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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The emerging role non-coding RNAs in B cell-related disorders.

Soudeh Ghafouri-Fard1, Tayyebeh Khoshbakht2, Bashdar Mahmud Hussen3,4

  • 1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cancer Cell International
|February 23, 2022
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Summary

Non-coding RNAs, including long non-coding RNAs and microRNAs, are crucial in B cell development and lymphomagenesis. Their specific expression patterns offer potential as biomarkers for B cell malignancies and immune disorders.

Keywords:
B cellExpressionImmune systemlncRNAmiRNA

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Area of Science:

  • * Molecular Biology
  • * Immunology
  • * Genetics

Background:

  • * Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are key regulators in cellular processes.
  • * Aberrant expression of these non-coding RNAs is implicated in B cell malignancies and immune disorders.
  • * Non-coding RNAs influence immune responses to infections and autoimmune diseases.

Purpose of the Study:

  • * To review the critical roles of non-coding RNAs in B cell development.
  • * To explore the involvement of lncRNAs and miRNAs in lymphomagenesis.
  • * To highlight the potential of non-coding RNAs as biomarkers for B cell malignancies.

Main Methods:

  • * Comprehensive literature review of studies on non-coding RNAs in B cell biology.
  • * Analysis of research investigating specific lncRNAs and miRNAs in B cell malignancies.
  • * Synthesis of findings on the diagnostic and prognostic potential of non-coding RNAs.

Main Results:

  • * Specific lncRNAs (e.g., MALAT1, NEAT1) and miRNAs (e.g., miR-155, miR-146a) are significantly associated with B cell malignancies.
  • * Non-coding RNA expression profiles are cell type-specific, suggesting biomarker utility.
  • * Dysregulation of non-coding RNAs contributes to the pathogenesis of B cell lymphomas and immune-related disorders.

Conclusions:

  • * Non-coding RNAs play integral roles in B cell lineage development and lymphomagenesis.
  • * Aberrantly expressed non-coding RNAs represent promising biomarkers for early detection and therapeutic targeting of B cell malignancies.
  • * Further research into non-coding RNA functions can advance understanding of B cell-associated diseases.