The emerging role non-coding RNAs in B cell-related disorders
Soudeh Ghafouri-Fard1, Tayyebeh Khoshbakht2, Bashdar Mahmud Hussen3,4
1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cancer Cell International
|February 23, 2022
Summary
Non-coding RNAs, including long non-coding RNAs and microRNAs, are crucial in B cell development and lymphomagenesis. Their specific expression patterns offer potential as biomarkers for B cell malignancies and immune disorders.
Area of Science:
- * Molecular Biology
- * Immunology
- * Genetics
Background:
- * Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are key regulators in cellular processes.
- * Aberrant expression of these non-coding RNAs is implicated in B cell malignancies and immune disorders.
- * Non-coding RNAs influence immune responses to infections and autoimmune diseases.
Purpose of the Study:
- * To review the critical roles of non-coding RNAs in B cell development.
- * To explore the involvement of lncRNAs and miRNAs in lymphomagenesis.
- * To highlight the potential of non-coding RNAs as biomarkers for B cell malignancies.
Main Methods:
- * Comprehensive literature review of studies on non-coding RNAs in B cell biology.
- * Analysis of research investigating specific lncRNAs and miRNAs in B cell malignancies.
- * Synthesis of findings on the diagnostic and prognostic potential of non-coding RNAs.
Main Results:
- * Specific lncRNAs (e.g., MALAT1, NEAT1) and miRNAs (e.g., miR-155, miR-146a) are significantly associated with B cell malignancies.
- * Non-coding RNA expression profiles are cell type-specific, suggesting biomarker utility.
- * Dysregulation of non-coding RNAs contributes to the pathogenesis of B cell lymphomas and immune-related disorders.
Conclusions:
- * Non-coding RNAs play integral roles in B cell lineage development and lymphomagenesis.
- * Aberrantly expressed non-coding RNAs represent promising biomarkers for early detection and therapeutic targeting of B cell malignancies.
- * Further research into non-coding RNA functions can advance understanding of B cell-associated diseases.
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