Choroidal vascularity index of patients with coronary artery disease
Won-Woo Seo1, Hyo Soon Yoo2,3, Yong Dae Kim2
1Division of Cardiology, Department of Internal Medicine, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, #150 Seongan-ro, Gangdong-gu, Seoul, 05355, South Korea.
Insights
Choroidal vascularity index (CVI) may indicate severe coronary artery disease (CAD). Lower CVI levels were associated with triple-vessel disease, suggesting its potential as a biomarker for advanced CAD.
Area of Science:
- Ophthalmology
- Cardiology
- Medical Imaging
Background:
- Coronary artery disease (CAD) poses a significant health burden.
- Subfoveal choroidal thickness and choroidal vascularity index (CVI) are ocular parameters.
- The relationship between these ocular parameters and CAD severity is not fully understood.
Purpose of the Study:
- To investigate changes in subfoveal choroidal thickness and CVI.
- To determine the association of these parameters with coronary artery stenosis severity.
- To evaluate their predictive value for triple-vessel disease.
Main Methods:
- Ninety patients with suspected CAD underwent coronary angiography.
- Subfoveal choroidal thickness and CVI were measured.
- Patients were categorized into no CAD, one-to-two-vessel disease, and triple-vessel disease groups.
Main Results:
- No significant difference in subfoveal choroidal thickness was observed across groups.
- Choroidal vascularity index (CVI) was significantly lower in the triple-vessel disease group.
- Male sex, hypertension, and lower CVI were significant predictors of triple-vessel disease.
Conclusions:
- Subfoveal choroidal thickness does not appear to correlate with CAD severity.
- Choroidal vascularity index (CVI) may serve as an indicator of severe coronary artery disease.
- CVI could be a valuable biomarker for identifying patients with advanced CAD.
Abstract:
We investigated the changes in subfoveal choroidal thickness and choroidal vascularity index (CVI) and their relationship with the severity of coronary artery stenosis in patients with cardiovascular risk factors and symptoms suggestive of coronary artery disease (CAD). Ninety patients who underwent coronary angiography (CAG) for evaluation of their coronary artery status and cardiac symptoms were included. Forty-two patients showed no evidence of CAD; 31 patients had one to two vessel disease; and 17 had a triple vessel disease. There were no significant differences in the subfoveal choroidal thickness among the three groups; however, the CVI in the triple vessel disease group was lower than those in the other groups. The CVI values were good predictors of the presence of triple-vessel disease (p = 0.020). Multivariate logistic regression analysis results revealed that male sex (odds ratio 5.4, p = 0.049), hypertension (odds ratio 4.9, p = 0.017), and CVI (%, odds ratio 0.8, p = 0.016) were significant factors associated with the presence of triple vessel disease. Although CVI may not be a sensitive marker for detecting early changes in the coronary artery, it may be helpful in indicating severe CAD.
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