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Bioavailability and Safety of Dihydroquercetin (Review)
S V Orlova1, V V Tatarinov2, E A Nikitina1
1Peoples' Friendship University of Russia (RUDN), 6 Miklukho-Maklaya St., Moscow, 117198 Russia.
Pharmaceutical Chemistry Journal
|February 23, 2022
Summary
Dihydroquercetin (DHQ), a potent antioxidant, shows promise for COVID-19 therapy. Innovative methods are explored to enhance its low bioavailability, improving its therapeutic potential.
Area of Science:
- Pharmacology and Biochemistry
- Infectious Diseases
- Biotechnology
Background:
- Dihydroquercetin (DHQ) is a bioflavonoid with demonstrated antioxidant, anti-inflammatory, and capillary-protective properties.
- DHQ has been investigated for Middle East respiratory syndrome coronavirus (MERS-CoV) and is considered for COVID-19 therapy due to its role in regulating oxidative stress.
- A significant limitation of DHQ is its low bioavailability, hindering its clinical application.
Purpose of the Study:
- To explore innovative techniques for enhancing the bioavailability of Dihydroquercetin (DHQ).
- To assess the potential of DHQ as a component of multipurpose COVID-19 therapy.
- To overcome the bioavailability challenges of DHQ for improved therapeutic efficacy.
Main Methods:
- Review of existing literature on Dihydroquercetin (DHQ) properties and applications.
- Investigation of advanced formulation strategies such as liposomization and crystal engineering.
- Analysis of DHQ's role in managing oxidative stress related to viral infections.
Main Results:
- Dihydroquercetin (DHQ) possesses significant antioxidant and anti-inflammatory activities relevant to viral infections.
- Low bioavailability is a key challenge restricting DHQ's therapeutic use.
- Techniques like liposomization and crystal engineering show potential for improving DHQ bioavailability.
Conclusions:
- Dihydroquercetin (DHQ) is a promising therapeutic agent for COVID-19 and other conditions due to its beneficial properties.
- Enhancing DHQ bioavailability through innovative techniques is crucial for realizing its full clinical potential.
- Further research into optimized DHQ formulations is warranted for effective disease management.
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