Innate immune memory and its application to artificial immune systems

The study of innate immune-based algorithms is an important research domain in Artificial Immune System (AIS), such as Dendritic Cell Algorithm (DCA), Toll-Like Receptor algorithm (TLRA). The parameters in these algorithms usually require either manually pre-defined usually provided by the immunologists, or empirically derived from the training dataset, and result in poor self-adaptation and self-learning. The fundamental reason is that the original innate immune mechanisms lack adaptive biological theory. To solve this problem, a theory called ‘Trained Immunity™ or Innate Immune Memory (IIM)™ that thinks innate immunity can also build immunological memory to enhance the immune system™s learning and adaptive reactions to the second stimulus is introduced into AIS to improve the innate immune algorithms™ adaptability. In this study, we present an overview of IIM with particular emphasis on analogies in the AIS world, and a modified DCA with an effective automated tuning mechanism based on IIM (IIM-DCA) to optimize migration threshold of DCA. The migration threshold of Dendritic Cells (DCs) determines the lifespan of the antigen collected by DCs, and directly affect the detection speed and accuracy of DCA. Experiments on real datasets show that our proposed IIM-DCA which integrates Innate Immune Memory mechanism delivers more accurate results.