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Related Experiment Video

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Modeling the Functional Network for Spatial Navigation in the Human Brain
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Task-related connectivity of decision points during spatial navigation in a schematic map.

Qing Qi1,2,3,4, Yihe Weng1,2,3,4, Senning Zheng1,2,3,4

  • 1School of Psychology, South China Normal University, Guangzhou, 510631, China.

Brain Structure & Function
|February 23, 2022
PubMed
Summary

Researchers identified key brain regions involved in making navigational decisions using a subway map. The study highlights cooperative interactions between the hippocampus, ventromedial prefrontal cortex, and retrosplenial cortex during spatial navigation.

Keywords:
GoalPsychophysiological interactionsRoute directionsWayfinding

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Spatial Navigation Research

Background:

  • Navigational decision-making is crucial for successful spatial navigation.
  • The neural underpinnings of decision-making at navigational points within schematic maps remain poorly understood.

Purpose of the Study:

  • To investigate the neural basis of decision-making at navigational points using a schematic map.
  • To explore the functional interactions between brain regions during spatial navigation tasks.

Main Methods:

  • Utilized a 2D subway paradigm for a spatial navigation task.
  • Employed functional Magnetic Resonance Imaging (fMRI) with 28 subjects.
  • Applied voxel-wise General Linear Model (GLM) and Psychophysiological Interactions (PPI) analyses.

Main Results:

  • Identified activation in the left hippocampus (HIP), left parahippocampal gyrus (PHG), left ventromedial prefrontal cortex (vmPFC), and right retrosplenial cortex (RSC) at decision points.
  • Revealed cooperative interactions between the left vmPFC and right HIP with the right RSC.
  • Demonstrated cooperative interactions between the left HIP and left vmPFC at decision points.

Conclusions:

  • The left HIP, left PHG, left vmPFC, and right RSC are key brain regions involved in navigational decision-making on schematic maps.
  • Functional interactions between these regions, particularly vmPFC, HIP, and RSC, are critical for processing navigational choices.
  • These findings contribute to understanding the neural mechanisms of spatial navigation and decision-making.