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Updated: Oct 2, 2025

Quantification of Levator Ani Hiatus Enlargement by Magnetic Resonance Imaging in Males and Females with Pelvic Organ Prolapse
Published on: April 17, 2019
Intra-subject Variability in High Resolution Anorectal Manometry Using the London Classification: Diagnostic and
George Triadafilopoulos1, John O Clarke2, Afrin Kamal2
1Stanford University School of Medicine, Stanford, USA. vagt@stanford.edu.
Abstract:
This retrospective pilot study conducted on a community-based cohort of both men and women of various ages and underlying clinical presentations examined the durability and reproducibility of HR-ARM findings influencing their potential impact on clinical decision-making at the point of care (Jameson et al. in Br J Surg 81:1689-1692, 1994). The key finding of our study was that only a minority of patients who underwent repeat anorectal manometry as analyzed by the London Classification had stable manometric findings, raising questions regarding the validity of a single manometric measurement, as currently analyzed, for clinical decision-making.
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